Treg Reutiman

Lymphatic-localized Treg-mregDC crosstalk limits antigen trafficking ... • cell.com

You et al. show that Tregs are specifically recruited to peri-lymphatic stroma region of colorectal cancer by mregDC forming Treg-mregDC-lymphatic niche, where they acquire activation signature and restrain the trafficking of the tumor antigens to the draining lymph nodes, thereby impeding the initiation of anti-tumor adaptive immune responses.

Regulation of Treg cells by cytokine signaling and co-stimulatory ... • nih.gov

Abstract. CD4 + CD25 + Foxp3 + regulatory T cells (Tregs), a vital component of the immune system, are responsible for maintaining immune homeostasis and preventing excessive immune responses. This review explores the signaling pathways of the cytokines that regulate Treg cells, including transforming growth factor beta (TGF-β), interleukin (IL)-2, IL-10, and IL-35, which foster the ...

Protocol for in vitro isolation, induction, expansion, and ... • sciencedirect.com

Regulatory T cells (Tregs) can inhibit the occurrence of autoimmune diseases and increase the activation threshold of the immune response. Here, we present schemes for the isolation and culture of natural human regulatory T cells (nTregs) and in vitro-induced Tregs (iTregs).Appropriate concentrations of TGF-β, IL-2, retinoic acid (atRA), and rapamycin were used to promote proliferation to ...

Human Regulatory T Cells: Understanding the Role of Tregs in Select ... • nih.gov

An alternative to polyclonal Tregs is the use of antigen-specific Tregs, a form of adoptive Treg therapy that offers a more targeted solution and requires the injection of fewer cells. The classic approach for designing antigen-specific Tregs utilizes either APCs and distinct antigens or engineered T cell receptors (TCRs) [ 229 ].

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Regulatory T cell function in autoimmune disease - PMC • nih.gov

Regulatory T cells play a major role in autoimmune and inflammatory diseases. Dysfunction of Tregs as well as unresponsiveness of effector T cells can cause and aggravate the clinical outcome. Tools to boost Treg function represent a valuable therapeutic option and could hold a promise for the treatment of autoimmune diseases in the future.

Interruption of the intratumor CD8+ T cell:Treg crosstalk improves the ... • cell.com

PD-1 blockade unleashes potent antitumor activity in CD8 + T cells but can also promote immunosuppressive T regulatory (Treg) cells, which may worsen the response to immunotherapy. Tumor-Treg inhibition is a promising strategy to improve the efficacy of checkpoint blockade immunotherapy; however, our understanding of the mechanisms supporting tumor-Tregs during PD-1 immunotherapy is incomplete.

Mitochondrial mechanisms in Treg cell regulation: Implications for ... • sciencedirect.com

Tregs, characterized by the expression of the transcription factor forkhead box P3 (FoxP3), play a pivotal role in the maintenance of immune homeostasis and the prevention of autoimmune diseases (Sakaguchi et al., 2008).These cells exert their immunoregulatory effects through a variety of mechanisms, including the secretion of anti-inflammatory cytokines such as interleukin-10 (IL-10) and ...

Diversity and function of regulatory T cells in health and autoimmune ... • sciencedirect.com

Treg heterogeneity, characterized by diverse gene expression profiles and functional states, is complex in both health and disease. Research reveals that Tregs are not a uniform population but exhibit diversity based on their origin, location, and functional status. This heterogeneity is crucial for understanding Treg roles in various ...