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Dihydropyrimidine dehydrogenase (DPD) is an enzyme that is involved in pyrimidine degradation that in humans is encoded by the DPYD gene. It is the initial and rate-limiting step in pyrimidine catabolism. [citation needed] It catalyzes the reduction of uracil and thymine.It is also involved in the degradation of the chemotherapeutic drugs 5-fluorouracil and tegafur.. You can find more here.
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