Amy Ooi

Amy O godi, age 40s, Saint Louis, MO View Details

Locations: Saint Louis MO, Barnhart MO Possible Relatives: Dennis T Godi, Joann E Godi, Michael D Godi

Amy See Ooi, age 40s, Dallas, TX View Details

Locations: Dallas TX, Tucson AZ, Conway AR

Amy Woorussell, age 40s, Mechanicsville, VA View Details

Locations: Mechanicsville VA, Richmond VA, Henrico VA Possible Relatives: Gale Elizabeth Bryant, Keith A Lewis, Clint Troy Russell

Amy M Oppenheim, age 40s View Details

Possible Relatives: Bert N Oppenheim, Cynthia H Oppenheim, Amy Seaman

Amy C Bumstead, age 50s, Richland, MI View Details

Locations: Richland MI, Ross Township MI, Ross MI Possible Relatives: Amy C Obrien, Catherine R Obrien, Jeffrey Cannon Obrien

Amy P Ooi, age 50s, San Antonio, TX View Details

Locations: San Antonio TX Possible Relatives: Tan, Kea Ong Tan, Kenny Tan

Amy Oo View Details

Possible Relatives: Lan Hue, Cuong Chi Oo, Dung Le Oo

Amy Ooi View Details

Address:***** Grissom Rd, San Antonio, TX

Amyloidosis

Amyloidosis is a group of diseases in which abnormal proteins, known as amyloid fibrils, build up in tissue. There are several types with varying symptoms; signs and symptoms may include diarrhea, weiread more...ght loss, feeling tired, enlargement of the tongue, bleeding, numbness, feeling faint with standing, swelling of the legs, or enlargement of the spleen.read less...

Amyloid beta

Amyloid beta denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. The peptides derive from the amyloid preread more...cursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ in a cholesterol dependent process and substrate presentation. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection. The oligomers are toxic to nerve cells. The other protein implicated in Alzheimer's disease, tau protein, also forms such prion-like misfolded oligomers, and there is some evidence that misfolded Aβ can induce tau to misfold.read less...

Amyloid

Amyloids are aggregates of proteins characterised by a fibrillar morphology of 7–13 nm in diameter, a β-sheet secondary structure and ability to be stained by particular dyes, such as Congo red. Inread more... the human body, amyloids have been linked to the development of various diseases. Pathogenic amyloids form when previously healthy proteins lose their normal structure and physiological functions (misfolding) and form fibrous deposits in plaques around cells which can disrupt the healthy function of tissues and organs.read less...

Amyloid-beta precursor protein

Amyloid-beta precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. It functions as a cell surface receptor and has been implicread more...ated as a regulator of synapse formation, neural plasticity, antimicrobial activity, and iron export. It is coded for by the gene APP and regulated by substrate presentation. APP is best known as the precursor molecule whose proteolysis generates amyloid beta (Aβ), a polypeptide containing 37 to 49 amino acid residues, whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients.read less...

Amyloid plaques

Amyloid plaques are extracellular deposits of the amyloid beta (Aβ) protein mainly in the grey matter of the brain. Degenerative neuronal elements and an abundance of microglia and astrocytes can be read more...associated with amyloid plaques. Some plaques occur in the brain as a result of senescence (aging), but large numbers of plaques and neurofibrillary tangles are characteristic features of Alzheimer's disease. Abnormal neurites in amyloid plaques are tortuous, often swollen axons and dendrites. The neurites contain a variety of organelles and cellular debris, and many of them include characteristic paired helical filaments, the ultrastructural component of neurofibrillary tangles. The plaques are highly variable in shape and size; in tissue sections immunostained for Aβ, they comprise a log-normal size distribution curve with an average plaque area of 400-450 square micrometers (µm²). The smallest plaques, which often consist of diffuse deposits of Aβ, are particularly numerous. The apparent size of plaques is influenced by the type of stain used to detect them, and by the plane through which they are sectioned for analysis under the microscope. Plaques form when Aβ misfolds and aggregates into oligomers and longer polymers, the latter of which are characteristic of amyloid. Misfolded and aggregated Aβ is thought to be neurotoxic, especially in its oligomeric state.read less...

Amyloid-related imaging abnormalities

Amyloid-related imaging abnormalities (ARIA) are abnormal differences seen in magnetic resonance imaging of the brain of Alzheimer's disease patients, associated with amyloid-modifying therapies, partread more...icularly human monoclonal antibodies such as aducanumab. There are two types of ARIA - ARIA-E and ARIA-H. The phenomenon was first seen in trials of bapineuzumab.read less...